background and aims:il-22 is an α-helical cytokine.il-22 binds to a heterodimeric cell surface receptor composed of il-10r2 and il-22r1subunits.il-22r is expressed on tissue cells and it is absent on immune cells.il-22 and il-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. the aim of this study was to investigat...

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We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family. No high affinity ligand has yet been reported for this receptor, although it has been reported to serve as a second component in IL-10 signaling. A new membe...

Murine genital tract infection with Neisseria gonorrhoeae has previously been found to induce IL-17 which is important in both recruitment of neutrophils and prompt clearance of the infection. As IL-22 is another Th17-related cytokine that has been implicated in the immune responses in several infection models, we investigated its role in vaginal gonococcal infection of mice. Production of IL-2...